Over one-half of pediatric patients and three-fourths of adults are reported to be non-compliant with current asthma medications. This technology improves compliance over inhaled medications with small molecule drugs that are orally active.
Asthma pill avoids inhaler delivery and corticosteroid side effects
Inventors at the University of Wisconsin-Milwaukee and Columbia University have developed lead drug compounds for asthma based on a fundamentally novel mechanism of action. These small molecule drugs are orally active, improving compliance over inhaled medications. The drugs target functional gamma-amino butyric acid type A receptors (GABAAR) expressed on airway smooth muscle and immune/inflammatory cells, avoiding the use of corticosteroids and adrenergic agonists.
US9879020B2 “GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma” (expiration 2033)
US11447495B2 “Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators” (expiration 2039)
AU2017313753A1 “GABA(A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma” (expiration 2037)
EP3500573B1 “Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma” (expiration 2037)
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