Pharmaceuticals, Agriculture, Food Processing, Chemical and Petrochemicals.
Inventors at University of Wisconsin, Milwaukee (UWM) have developed snapshot optical tomography technique which can record the 3D tomogram of a micrometer to millimeter sized specimen in a single snapshot. In particular, snapshot holographic optical tomography (SHOT) can instantaneously record the 3D map of complex-valued refractive index (i.e., absorption and refractive index). Furthermore, snapshot projection optical tomography (SPOT) can also instantaneously record the 3D luminescence (e.g., fluorescence, bioluminescence, photoluminescence) when needed.
Chemical identification, including the 3D distribution of active pharmaceutical ingredients, excipient or lyophilizate distributions of tablets can be achieved by combining the tomograms with analysis techniques like FT-IR, Raman, and UV-visible spectroscopy. This technology can provide an opportunity for safe and accurate testing of 100% of tablet or capsule beads.