Protein purification, protein research, quantification of proteins, drug discovery, vaccine production, pharmaceuticals, affinity purification
In current antibody purification techniques, antibodies bind in a single layer on a surface of agar beads reducing overall yield and increasing retention time.
Dr. Ionel Popa at University of Wisconsin, Milwaukee (UWM) has developed a new class of protein hydrogels made from soluble proteins into a porous 3-dimensional stable network. This technology is faster and more efficient without an increased cost.
This new method to produce polyprotein-based hydrogels with micron-sized pores facilitate their interaction with large particles and molecules, such as antibodies with increased active surface area. Unlike regular methods, where the antibodies bind in a single layer on a surface of agar beads, our method produces binding sites throughout the material. This method offers a much higher surface density of binding sites and provides improved retention time and yield over current antibody purification methods. These protein-based porous hydrogels can be attractive candidates for purification of research-based or therapeutic antibodies used for a broad range of targets in oncology, immunology, hematology and many more prevalent medical applications.
PCT filed 2023.
Ionel Popa Associate Professor, Physics Department
Please contact our office to share your business’ needs.