Drug discovery, regeneration, bone healing, stem cell recruitment
Bones heal completely after fracture, but in cases like advanced age this process is substantially altered and can delay healing or lead to non-union of bone. This can result in changes in biomechanics of the bone leading to complications affecting quality of life. Also, studies support faster bone healing which can be useful for active military members. Current treatment strategies focus on downstream osteogenic factors, often showing limited success.
Dr. Priyatha Premnath is working to develop a new method of use for a known compound as a cell permeable p21 inhibitor. Inhibition of p21 can improve bone healing outcomes in p21 knockout mice. It has been demonstrated that mesenchymal stem cells (MSCs) play a vital role in the bone healing process, and in advanced age MSCs have reduced bone forming capacity. Recent mouse studies with the small molecule show accelerated bone healing after injury, and increased p21 expression in aged mice.
US Provisional Patent Filed Spring 2022.
Priyatha Premnath Ph.D., Assistant Professor, Biomedical Engineering
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