The add-on device may be attached to the existing research microscope via a side port that incorporates a femtosecond laser (as shown in the picture). This state-of-the-art imaging tool uses a single scan multiphoton excitation (425 to 650 nm wavelength range) to deliver pixel level spectral resolution of complex, multi-color fluorescence samples. This technology can upgrade the imaging capability of a variety of microscopes, enabling it to achieve multi-photon microscope grade with 3D spatial resolution. This is the only scanning system that permits real-time quantitative analysis of a single molecule, molecular complexes, and their spatial distribution in living cells. This technology also allows fluorescence signals from co-localized molecules in a three-dimensional sample to be resolved spectrally by parallel detection of tens or hundreds of wavelengths using an EMCCD camera without the need of Confocal setup.
US7,973,927 | US8,094,304 | US9,103,721 | US8,982,206 | EP20120782796 validated in BE, FR, DE, UK, and IE.
Lead Inventor:
Dr. Valerica Raicu
Professor of Physics